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Ophidian may refer to:
- Ophidian, a reptile of the suborder Ophidia (or Serpentes); a snake
- Ophidian (wrestler), a professional wrestler
- Ophidian (Dungeons & Dragons), a Dungeons & Dragons monster
- Ophidian 2350, a collectible card game
- Ophidian, a fictional hotel from the American TV show Supernatural
| disambiguation page lists articles associated with the title Ophidian.
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