PCDHB10

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PCDHB10
Identifiers
Aliases PCDHB10, PCDH-BETA10, PCHB10, protocadherin beta 10
External IDs HomoloGene: 56829 GeneCards: 56126
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018930

n/a

RefSeq (protein)

NP_061753.1

n/a

Location (UCSC) Chr 5: 141.18 – 141.2 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Protocadherin beta-10 is a protein that in humans is encoded by the PCDHB10 gene.[1][2]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[2]

References[edit]

  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHB10 protocadherin beta 10". 

Further reading[edit]