PDE8A
Template:PBB High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene.[1][2] Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.[3]
References
- ^ Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB (Jul 1998). "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase". Biochem Biophys Res Commun. 246 (3): 570–7. doi:10.1006/bbrc.1998.8684. PMID 9618252.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: PDE8A phosphodiesterase 8A".
- ^ Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, Strauss JF 3rd, Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB (Sep 2011). "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages". Virology. 420 (1): 32–42. doi:10.1016/j.virol.2011.08.013. PMID 21920574.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)
Further reading
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