PLD2

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Monkbot (talk | contribs) at 16:40, 28 January 2014 (Fix CS1 deprecated date parameter errors). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Template:PBB Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene.[1][2]

Template:PBB Summary

Interactions

PLD2 has been shown to interact with BIN1,[3] Amphiphysin,[3] Aldolase A,[4] PLCG1,[5] ARF1,[6][7] Src,[8] PRKCD,[9] Glyceraldehyde 3-phosphate dehydrogenase,[10] Caveolin 1,[11][12] and Wiskott-Aldrich syndrome protein.[13]

Inhibitors

  • N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide: 75-fold selective versus PLD1, IC50 = 20 nM.[14]

References

  1. ^ Park SH, Ryu SH, Suh PG, Kim H (February 1999). "Assignment of human PLD2 to chromosome band 17p13.1 by fluorescence in situ hybridization". Cytogenet Cell Genet. 82 (3–4): 225. doi:10.1159/000015106. PMID 9858823.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Lopez I, Arnold RS, Lambeth JD (June 1998). "Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2". J Biol Chem. 273 (21): 12846–52. doi:10.1074/jbc.273.21.12846. PMID 9582313.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  3. ^ a b Lee, C (June 2000). "Inhibition of phospholipase D by amphiphysins". J. Biol. Chem. 275 (25). UNITED STATES: 18751–8. doi:10.1074/jbc.M001695200. ISSN 0021-9258. PMID 10764771. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  4. ^ Kim, Jong Hyun (March 2002). "Phospholipase D2 directly interacts with aldolase via Its PH domain". Biochemistry. 41 (10). United States: 3414–21. doi:10.1021/bi015700a. ISSN 0006-2960. PMID 11876650. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  5. ^ Jang, Il Ho (May 2003). "The direct interaction of phospholipase C-gamma 1 with phospholipase D2 is important for epidermal growth factor signaling". J. Biol. Chem. 278 (20). United States: 18184–90. doi:10.1074/jbc.M208438200. ISSN 0021-9258. PMID 12646582. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  6. ^ Lee, S (July 2001). "Actin directly interacts with phospholipase D, inhibiting its activity". J. Biol. Chem. 276 (30). United States: 28252–60. doi:10.1074/jbc.M008521200. ISSN 0021-9258. PMID 11373276. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  7. ^ Park, J B (July 2000). "Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner". J. Biol. Chem. 275 (28). UNITED STATES: 21295–301. doi:10.1074/jbc.M002463200. ISSN 0021-9258. PMID 10801846. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  8. ^ Ahn, Bong-Hyun (May 2003). "Transmodulation between phospholipase D and c-Src enhances cell proliferation". Mol. Cell. Biol. 23 (9). United States: 3103–15. doi:10.1128/MCB.23.9.3103-3115.2003. ISSN 0270-7306. PMC 153190. PMID 12697812. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  9. ^ Han, Jung Min (March 2002). "Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells". J. Biol. Chem. 277 (10). United States: 8290–7. doi:10.1074/jbc.M108343200. ISSN 0021-9258. PMID 11744693. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  10. ^ Kim, Jung Hwan (June 2003). "Hydrogen peroxide induces association between glyceraldehyde 3-phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells". J. Neurochem. 85 (5). England: 1228–36. doi:10.1046/j.1471-4159.2003.01755.x. ISSN 0022-3042. PMID 12753082. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  11. ^ Zheng, Xiangjian (December 2003). "Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane microdomains and is downregulated upon keratinocyte differentiation". J. Invest. Dermatol. 121 (6). United States: 1487–95. doi:10.1111/j.1523-1747.2003.12614.x. ISSN 0022-202X. PMID 14675200. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  12. ^ Czarny, M (February 2000). "Phospholipase D2: functional interaction with caveolin in low-density membrane microdomains". FEBS Lett. 467 (2–3). NETHERLANDS: 326–32. doi:10.1016/S0014-5793(00)01174-1. ISSN 0014-5793. PMID 10675563. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  13. ^ Kantonen, S (November 2011). "A Novel Phospholipase D2-Grb2-WASp Heterotrimer Regulates Leukocyte Phagocytosis in a Two-Step Mechanism". Mol Cell Biol. 31 (22). UNITED STATES: 4524–37. doi:10.1128/MCB.05684-11. PMC 3209255. PMID 21930784. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laydate=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  14. ^ Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels JS, Brown HA, Lindsley CW (September 2010). "Design, Synthesis, and Biological Evaluation of Halogenated N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: Discovery of an Isoform-Selective Small Molecule Phospholipase D2 Inhibitor". J. Med. Chem. 53 (18): 6706–19. doi:10.1021/jm100814g. PMID 20735042.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Further reading

Template:PBB Further reading

Template:PBB Controls


Stub icon

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=PLD2&oldid=592814836"