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Pvt1 oncogene (non-protein coding), also known as PVT1 , is a long non-coding RNA gene .[ 3] mice , this gene was identified as a breakpoint site in chromosome 6;15 translocations . These translocations are associated with murine plasmacytomas .[ 4] Burkitt's lymphoma .[ 5] rats , this breakpoint was shown to be a common site of proviral integration in retrovirally induced T lymphomas .[ 6] Transcription of PVT1 is regulated by Myc .[ 7]
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References
^ a b c GRCh38: Ensembl release 89: ENSG00000249859 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: PVT1 Pvt1 oncogene homolog, MYC activator (mouse)" .^ Cory S, Graham M, Webb E, Corcoran L, Adams JM (1985). "Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene" . EMBO J . 4 (3): 675–81. PMC 554241 PMID 3924592 . ^ Graham M, Adams JM (1986). "Chromosome 8 breakpoint far 3' of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus" . EMBO J . 5 (11): 2845–51. PMC 1167233 PMID 3024964 . ^ Villeneuve L, Rassart E, Jolicoeur P, Graham M, Adams JM (1986). "Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas" . Mol Cell Biol . 6 (5): 1834–7. PMC 367714 PMID 3785181 . ^ Carramusa L, Contino F, Ferro A, Minafra L, Perconti G, Giallongo A, et al. (2007). "The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells". J Cell Physiol . 213 (2): 511–8. doi :10.1002/jcp.21133 . PMID 17503467 .
Further reading
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