Parathyroid hormone family

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Parathyroid hormone family

The parathyroid hormone family is a family of structurally and functionally related proteins. Parathyroid hormone (PTH) is a polypeptidic hormone primarily involved in calcium metabolism. The parathyroid hormone-related protein (PTH-rP) is a related protein with predominantly paracrine function and possibly an endocrine role in lactation, as PTHrP has been found to be secreted by mammary glands into the circulation and increase bone turnover.[1][2] PTH and PTH-rP bind to the same G-protein coupled receptor.[3] The related protein PTH-L has been found in teleost fish, which also have two forms of PTH and PTHrP.[4] Three subfamilies can be identified: PTH, PTHrP and PTH-L.[5]

Human proteins containing this domain[edit]


  1. ^ VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ (November 2003). "Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation". J. Clin. Invest. 112 (9): 1429–36. doi:10.1172/JCI19504. PMC 228471. PMID 14597768.
  2. ^ McCauley LK, Martin TJ (June 2012). "Twenty-five years of PTHrP progress: from cancer hormone to multifunctional cytokine". J. Bone Miner. Res. 27 (6): 1231–9. doi:10.1002/jbmr.1617. PMC 4871126. PMID 22549910.
  3. ^ Martin TJ, Allan EH, Caple IW, Care AD, Danks JA, Diefenbach-Jagger H, Ebeling PR, Gillespie MT, Hammonds G, Heath JA (1989). "Parathyroid hormone-related protein: isolation, molecular cloning, and mechanism of action". Recent Prog. Horm. Res. 45: 467–502, discussion 502–6. PMID 2682846.
  4. ^ Pinheiro PL, Cardoso JC, Gomes AS, Fuentes J, Power DM, Canário AV (2010). "Gene structure, transcripts and calciotropic effects of the PTH family of peptides in Xenopus and chicken". BMC Evol. Biol. 10: 373. doi:10.1186/1471-2148-10-373. PMC 3009671. PMID 21122104.
  5. ^ Guerreiro PM, Renfro JL, Power DM, Canario AV (February 2007). "The parathyroid hormone family of peptides: structure, tissue distribution, regulation, and potential functional roles in calcium and phosphate balance in fish". Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 (2): R679–96. doi:10.1152/ajpregu.00480.2006. PMID 17023665.
This article incorporates text from the public domain Pfam and InterPro: IPR001415