Pedro Julio Astacio (born November 28, 1968) is a former Major League Baseball pitcher. He has played for the Los Angeles Dodgers (1992–1997), Colorado Rockies (1997–2001), Houston Astros (2001), New York Mets (2002–2003), Boston Red Sox (2004), Texas Rangers (2005), the San Diego Padres (2005) and the Washington Nationals (2006). In 2007, Astacio signed a contract with the Nationals' Triple-A affiliate, the Columbus Clippers, but they released him in May.
Astacio currently holds the record for the most career strikeouts by a member of the Colorado Rockies, with 749 strikeouts between 1997 and 2001. He was also a member of the 2004 Boston Red Sox team that won their first World Series since 1918.