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Penicillium nordicum

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Penicillium nordicum
Scientific classification Edit this classification
Domain: Eukaryota
Kingdom: Fungi
Division: Ascomycota
Class: Eurotiomycetes
Order: Eurotiales
Family: Aspergillaceae
Genus: Penicillium
Species:
P. nordicum
Binomial name
Penicillium nordicum
Dragoni & Cantoni ex C. Ramírez 1985[1]

Penicillium nordicum is an anamorph species of fungus in the genus Penicillium which produces ochratoxin A.[1][2][3][4] Penicillium nordicum contaminates protein rich foods and foods with high NaCl-konzentration.[3][5] It is mostly found on dry-cured meat products and cheese products[3][6]

Spoilage in the food industry

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P. nordicum is one of several species (specific of the genus Aspergillus and Penicillium) that produces Ochratoxin A. Ochratoxin A is a mycotoxin that is a known contaminant of several food sources since it is stable in acidic environments, is difficult to ensure adequate sterilization from it through cooking, and is made by species that persist in high salt and low-temperature.[7] environments. P. nordicum is commonly found on dried meats, like salami and cured ham, as well as other food products like cheese rinds. All of these foods are highly salted and protein-rich.[8] Besides being isolated from the surface of these foods, it has also been isolated from the air of such storage facilities in various European factories. For the contaminated meat products, P. nordicum was isolated from the salt used to season the products in several cases, indicating a similarity in raw material contamination. However, the overlapping morphological profile of P. nordicum and P. nalgiovense can make initial identification of a P. nordicum contamination difficult for the naked eye.[3]

Ecological niche of P. nordicum

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P. nordicum is a psychrophilic fungus that has been isolated from Arctic environments, specifically from Arctic glaciers, seawater, and sea ice.[9] The Arctic niche is characterized by low temperature, water movement, and high salt content which is rarer for fungal abundance and subsequent isolation. Several Penicillium species have been isolated from this niche and the species noted also are not known to grow in temperate, for example, soil, environments. There is a high degree of similarity between the Penicillium species that are found in food and the Arctic environment.[10] Given the high salinity of these environments, one proposed mechanism of common contamination is through the sea salt used to season dried meats. Since it is known that P. nordicum can successfully grow in low-temperature environments as well, the storage conditions for dried meat curing overlap with the fungal niche.[3]

Biocontrol of P. nordicum

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Fungal contamination is a large problem in the food industry as it can render massive quantities of food inedible. Ochratoxin A is produced by P. nordicum and can lead to renal failure or tumor formation by inhibiting protein synthesis, decreasing cellular energy production, resulting in genotoxic effects, inducing oxidative stress, or inciting apoptosis.[11] One potential avenue to prevent Ochratoxin A consumption via eliminating P. nordicum is through biotic control and the use of protective cultures. Concurrent inoculation of two species before ripening, Debaryomyces hansenii and Staphylococcus xylosus, resulted in decreased Ochratoxin A production, potentially related to the repression of genes in the OTA biosynthesis pathway.[12] In addition, certain lactic acid bacteria have also demonstrated an ability to decrease OTA production in P. nordicum, which is consequently beneficial as several species have probiotic properties. One proposed mechanism for this interaction is that the organic acids produced by LABs enter the microbe of interest and disrupt metabolic activity, potentially by altering pH.[13]

Further reading

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  • Virgili, R; Simoncini, N; Toscani, T; Camardo Leggieri, M; Formenti, S; Battilani, P (2012). "Biocontrol of Penicillium nordicum growth and ochratoxin a production by native yeasts of dry cured ham". Toxins. 4 (2): 68–82. doi:10.3390/toxins4020068. PMC 3317108. PMID 22474567.
  • Berni, E.; Degola, F.; Cacchioli, C.; Restivo, F. M.; Spotti, E. (2011). "Polyphasic approach for differentiating Penicillium nordicumfrom Penicillium verrucosum" (PDF). Food Additives & Contaminants: Part A. 28 (4): 477–84. doi:10.1080/19440049.2010.550065. PMID 21337229. S2CID 6249695.
  • Comi, G.; Chiesa, L.; Panseri, S.; Orlic, S.; Iacumin, L. (2013). "Evaluation of different methods to prevent Penicillium nordicumgrowth on and ochratoxin a production in country-style sausages". World Mycotoxin Journal. 6 (4): 411. doi:10.3920/WMJ2013.1548.
  • Färber, P.; Geisen, R. (2004). "Analysis of differentially-expressed ochratoxin a biosynthesis genes of Penicillium nordicum". Molecular Diversity and PCR-detection of Toxigenic Fusarium Species and Ochratoxigenic Fungi. pp. 661–669. doi:10.1007/978-1-4020-2285-2_20. ISBN 978-90-481-6631-2.
  • Battilani, P.; Formenti, S.; Toscani, T.; Virgili, R. (2010). "Influence of abiotic parameters on ochratoxin a production by a Penicillium nordicum strain in dry-cured meat model systems". Food Control. 21 (12): 1739. doi:10.1016/j.foodcont.2010.08.003.
  • Geisen, R. (2004). "Molecular monitoring of environmental conditions influencing the induction of ochratoxin a biosynthesis genes in Penicillium nordicum". Molecular Nutrition & Food Research. 48 (7): 532–540. doi:10.1002/mnfr.200400036. PMID 15538713.
  • Q. Ashton Acton (2012). Nasal Lubricants and Irrigations—Advances in Research and Application: 2012 Edition: ScholarlyBrief. ScholarlyEdition. ISBN 978-1481606806.
  • Antonio Logrieco; Angelo Visconti (2013). An Overview on Toxigenic Fungi and Mycotoxins in Europe. Springer Science & Business Media. ISBN 978-1402026461.

References

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  1. ^ a b MycoBank
  2. ^ UniProt
  3. ^ a b c d e Sonjak, S.; Ličen, M.; Frisvad, J. C.; Gunde-Cimerman, N. (2011). "Salting of dry-cured meat – A potential cause of contamination with the ochratoxin A-producing species Penicillium nordicum". Food Microbiology. 28 (6): 1111–6. doi:10.1016/j.fm.2011.02.007. PMID 21645808.
  4. ^ ATCC
  5. ^ John F. Leslie; Antonio Logrieco (2014). Mycotoxin Reduction in Grain Chains. John Wiley & Sons. ISBN 978-0813820835.
  6. ^ Ailsa D. Hocking; John I. Pitt; Robert A. Samson; Ulf Thrane (2006). Advances in Food Mycology. Springer Science & Business Media. ISBN 0387283919.
  7. ^ Frugier, Cécile; Bégin, Philippe (2022), "Food toxins", Reference Module in Food Science, Elsevier, doi:10.1016/b978-0-323-96018-2.00011-0, ISBN 978-0-08-100596-5, retrieved 2024-04-17
  8. ^ Sonjak, Silva; Ličen, Mia; Frisvad, Jens Christian; Gunde-Cimerman, Nina (September 2011). "Salting of dry-cured meat – A potential cause of contamination with the ochratoxin A-producing species Penicillium nordicum". Food Microbiology. 28 (6): 1111–1116. doi:10.1016/j.fm.2011.02.007.
  9. ^ Gunde-Cimerman, N.; Sonjak, S.; Zalar, P.; Frisvad, J.C.; Diderichsen, B.; Plemenitaš, A. (January 2003). "Extremophilic fungi in arctic ice: a relationship between adaptation to low temperature and water activity". Physics and Chemistry of the Earth, Parts A/B/C. 28 (28–32): 1273–1278. Bibcode:2003PCE....28.1273G. doi:10.1016/j.pce.2003.08.056.
  10. ^ Sonjak, Silva; Frisvad, Jens C.; Gunde-Cimerman, Nina (August 2006). "Penicillium Mycobiota in Arctic Subglacial Ice". Microbial Ecology. 52 (2): 207–216. Bibcode:2006MicEc..52..207S. doi:10.1007/s00248-006-9086-0. ISSN 0095-3628. PMID 16897300.
  11. ^ Kőszegi, Tamás; Poór, Miklós (2016-04-15). "Ochratoxin A: Molecular Interactions, Mechanisms of Toxicity and Prevention at the Molecular Level". Toxins. 8 (4): 111. doi:10.3390/toxins8040111. ISSN 2072-6651. PMC 4848637. PMID 27092524.
  12. ^ Cebrián, Eva; Núñez, Félix; Álvarez, Micaela; Roncero, Elia; Rodríguez, Mar (August 2022). "Biocontrol of ochratoxigenic Penicillium nordicum in dry-cured fermented sausages by Debaryomyces hansenii and Staphylococcus xylosus". International Journal of Food Microbiology. 375: 109744. doi:10.1016/j.ijfoodmicro.2022.109744. hdl:10662/17186. PMID 35660256.
  13. ^ Guimarães, Ana; Venancio, Armando; Abrunhosa, Luís (2018-09-02). "Antifungal effect of organic acids from lactic acid bacteria on Penicillium nordicum". Food Additives & Contaminants: Part A. 35 (9): 1803–1818. doi:10.1080/19440049.2018.1500718. hdl:1822/56381. ISSN 1944-0049.
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