Cancers with PNI usually have a poorer prognosis, as PNI is thought to be indicative of perineural spread, which can make resection of malignant lesions more difficult.
In one study, PNI was found in approximately 90% of radical prostatectomy specimens, and PNI outside of the prostate, especially, was associated with a poorer prognosis. However, there exists controversies about whether PNI has prognostic significance toward cancer malignancy.
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- Merrilees, AD.; Bethwaite, PB.; Russell, GL.; Robinson, RG.; Delahunt, B. (Sep 2008). "Parameters of perineural invasion in radical prostatectomy specimens lack prognostic significance". Mod Pathol. 21 (9): 1095–100. doi:10.1038/modpathol.2008.81. PMID 18500264.