Pestivirus internal ribosome entry site (IRES)

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Pestivirus internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Pesti
Symbol IRES_Pesti
Alt. Symbols Pesti_IRES
Rfam RF00209
Other data
RNA type Cis-reg; IRES
Domain(s) Viruses
GO 0043022
SO 0000243

This family represents the internal ribosome entry site (IRES) of the pestiviruses. The pestivirus IRES allows cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor, eIF4F.[1] The classical swine fever virus UTR described appears to be longer at the 5' end than other pestivirus UTRs.[1] This family represents the conserved core.


  1. ^ a b Kolupaeva, VG; Pestova TV; Hellen CU (2000). "Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA. 6 (12): 1791–1807. doi:10.1017/S1355838200000662. PMC 1370049Freely accessible. PMID 11142379. 

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