Urocortin
Template:PBB Urocortin is a protein that in humans is encoded by the UCN gene.[1][2][3] Template:PBB Summary Urocortin is a potent anorexigenic peptide of 40 amino acids that induces fed-like motor activity when administered centrally or peripherally in fasted animals. Urocortin belongs to the corticotropin-releasing factor (CRF) family that includes CRF, urotensin I, sauvagine, urocortin II and urocortin III. Urocortin is also a potent and long-lasting hypotensive agent and increases coronary blood flow.
Interactions
Urocortin has been shown to interact with Corticotropin releasing hormone receptor 1.[4][5]
References
- ^ Zhao L, Donaldson CJ, Smith GW, Vale WW (1999). "The structures of the mouse and human urocortin genes (Ucn and UCN)". Genomics. 50 (1): 23–33. doi:10.1006/geno.1998.5292. PMID 9628819.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Tsarev OB (1977). "[Dynamics of matrix synthesis in molecular biophysics. II. Principle of insertability and the single-valued solution of feedback tasks]". Biofizika. 22 (2): 197–200. PMID 861256.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ "Entrez Gene: UCN urocortin".
- ^ Donaldson, C J (1996). "Cloning and characterization of human urocortin". Endocrinology. 137 (5). UNITED STATES: 2167–70. doi:10.1210/en.137.5.2167. ISSN 0013-7227. PMID 8612563.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help); Unknown parameter|unused_data=ignored (help)CS1 maint: year (link) - ^ Gottowik, J (1997). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin". Neuropharmacology. 36 (10). ENGLAND: 1439–46. doi:10.1016/S0028-3908(97)00098-1. ISSN 0028-3908. PMID 9423932.
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Further reading
- Inui, Bowers, et al. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J. 2004 Mar;18(3):439-56. PMID: 15003990
- Huang Y, Yao XQ, Lau CW, Chan YC, Tsang SY, Chan FL. Urocortin and cardiovascular protection. Acta Pharmacol Sin. 2004 Mar;25(3):257-65.
- Takahashi, Kazuhiro. Translational medicine in fish-derived peptides: From fish endocrinology to human physiology and diseases. Endocrine Journal (Kyoto, Japan) (2004), 51(1), 1-17.
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