Phenylpropene is a chemical compound. The syllable '-en' in propene indicates the double bond, as opposed e.g. to phenylpropane. In plant biochemistry, phenylpropene is derived from the general shikimate/phenylpropanoid synthesis pathway, and belong to the immensely diverse and important class of phenylpropanoids. Phenylpropene is the scaffold for a class of derivatives called phenylpropenoids, that may also be called Phenylpropenes, propenylphenols, alkenylbenzenes or allylbenzenes.
Dosage determines concern: There is long standing and wide use as flavors at doses low enough to be insignificant, but high doses as in medicinal use can be a concern. Phenylpropene compounds are readily metabolized to reactive carcinogens which are also rapidly metabolized to safe compounds that are excreted. Thus the metabolism of these molecules quickly progresses from flavor to toxin to safe excretion.
Alkenylbenzenes at high dose can be activated metabolically (by P450, sulfotransferase) to reactive intermediates that bind DNA, but are also rapidly converted to less toxic dihydrodiol or glutathione conjugates.
- Substituted methylenedioxyphenethylamines
- Methyl eugenol
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