Pikachurin: Difference between revisions
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{{protein |
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| width = |
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| HGNCid = 26810 |
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| Symbol = EGFLAM |
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| AltSymbols = FLJ39155, AGRINL, AGRNL |
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| EntrezGene = 133584 |
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| OMIM = |
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| RefSeq = NM_152403 |
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| UniProt = Q63HQ2 |
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| PDB = |
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| ECnumber = |
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| Chromosome = 5 |
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| Arm = p |
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| Band = 13.1-13.2 |
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| LocusSupplementaryData = |
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}} |
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'''Pikachurin''' is an [[extracellular matrix]]-like [[retina]]l [[protein]] first described in 2008 in Japan by Shigeru Sato et al., and named after [[Pikachu]], the highly popular mascot of the [[Pokémon]] franchise.<ref name="pmid18641643">{{cite journal | author = Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T | title = Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation | journal = Nat. Neurosci. | volume = 11 | issue = 8 | pages = 923–31 | year = 2008 | month = August | pmid = 18641643 | doi = 10.1038/nn.2160 | url = | issn = }}</ref> The protein is colocalized with both [[dystrophin]] and [[dystroglycan]] at the [[ribbon synapse]]s. |
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Pikachurin is a dystroglycan-interacting protein which has an essential role in the precise interactions between the photoreceptor ribbon synapse and the bipolar dendrites. |
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The name of this "nimble" protein was inspired due to Pikachu's "lightning-fast moves and shocking electric effects".<ref>{{citenews|url=http://inventorspot.com/articles/lightningfast_vision_protein_named_after_pikachu_16170|title=Lightning-Fast Vision Protein Named After Pikachu|publisher=Inventor Spot|author=Levenstein, Steve|date=2008-07-24|accessdate=2008-07-29}}</ref> |
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Since Pikachurin seems to provide better visual acuity, Sato et al. of the [[Osaka Bioscience Institute]] believe that the protein could be used to develop a treatment for [[retinitis pigmentosa]] and other eye disorders.<ref name="pmid18641643"/><ref>{{cite news | url =http://www.yomiuri.co.jp/dy/features/science/20080722TDY02306.htm|title=Researchers: 'Pikachurin' protein linked with kinetic vision|publisher=[[Yomiuri Shimbun]]|date=2008-07-22|accessdate= 2008-07-22}}{{dead link|date=November 2008}}</ref> |
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==See also== |
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* [[Sonic hedgehog]], another protein named for a video game character. |
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* [[Zbtb7]], an [[oncogene]] that was originally named "Pokemon". |
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==References== |
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{{reflist|2}} |
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==External links== |
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* [http://inventorspot.com/articles/lightningfast_vision_protein_named_after_pikachu_16170 Lightning-Fast Vision Protein Named After Pikachu] - July 24, 2008 |
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[[Category:Proteins]] |
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{{neuroscience-stub}} |
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[[es:Pikachurina]] |
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[[it:Pikachurina]] |
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[[ja:ピカチュリン]] |
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[[ru:Пикачурин]] |
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