Potassium channel RNA editing signal

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Potassium channel RNA editing signal
RF00485.jpg
Predicted secondary structure and sequence conservation of K_chan_RES
Identifiers
SymbolK_chan_RES
RfamRF00485
Other data
RNA typeCis-reg
Domain(s)Eukaryota
SO0000233
PDB structuresPDBe

The potassium channel RNA editing signal is an RNA element found in human Kv1.1 and its homologues which directs the efficient modification of an adenosine to inosine by an adenosine deaminase acting on RNA (ADAR). The ADAR modification causes an isoleucine/valine recoding event which lies in the ion-conducting pore of the potassium channel. It is thought that this editing event targets the process of fast inactivation and allows a more rapid recovery from inactivation at negative potentials.[1]

References[edit]

  1. ^ Bhalla T, Rosenthal JJ, Holmgren M, Reenan R (October 2004). "Control of human potassium channel inactivation by editing of a small mRNA hairpin". Nature Structural & Molecular Biology. 11 (10): 950–956. doi:10.1038/nsmb825. PMID 15361858.

External links[edit]