Benzylpenicilloyl polylysine

Benzylpenicilloyl polylysine
Clinical data
Trade names	Pre-Pen
Other names	Pre-Pen
License data	US FDA: Pre-Pen;
Routes of; administration	Liquid intradermal
ATC code	none;
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name [2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate : L-Lysine homopolymer;
CAS Number	31855-75-1 ;
DrugBank	DB00895 ;
ChemSpider	none;
UNII	76479814OY;
ChEMBL	ChEMBL1201779 ;
CompTox Dashboard (EPA)	DTXSID00185720 ;
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Benzylpenicilloyl polylysine (Pre-Pen) is used as a skin test before the administration of penicillin. It is used to detect the immunoglobulin E antibodies.^[1]^[2] The chemical structure consists of the benzylpenicilloyl group attached to a polymer of L-lysine.^[3]^[4]^[5]

References

^ "Benzylpenicilloyl polylysine". PharmGKB.
^ "Benzylpenicilloyl polylysine". DrugBank.
^ Vemuri P, Harris KE, Suh LA, Grammer LC (2004). "Preparation of benzylpenicilloyl-polylysine: a preliminary study". Allergy and Asthma Proceedings. 25 (3): 165–168. PMID 15317320.
^ Goldschmidt BM, Levine BB (June 1983). "The preparation and determination of structure of benzylpenicilloyl compounds used in skin-testing for penicillin allergy". The Journal of Antibiotics. 36 (6): 709–714. doi:10.7164/antibiotics.36.709. PMID 6874593.
^ "PRE-PEN® (benzylpenicilloyl polylysine injection USP) Skin Test Antigen". DailyMed. U.S. National Library of Medicine.

[1] "Benzylpenicilloyl polylysine". PharmGKB.

[2] "Benzylpenicilloyl polylysine". DrugBank.

[3] Vemuri P, Harris KE, Suh LA, Grammer LC (2004). "Preparation of benzylpenicilloyl-polylysine: a preliminary study". Allergy and Asthma Proceedings. 25 (3): 165–168. PMID 15317320.

[4] Goldschmidt BM, Levine BB (June 1983). "The preparation and determination of structure of benzylpenicilloyl compounds used in skin-testing for penicillin allergy". The Journal of Antibiotics. 36 (6): 709–714. doi:10.7164/antibiotics.36.709. PMID 6874593.

[5] "PRE-PEN® (benzylpenicilloyl polylysine injection USP) Skin Test Antigen". DailyMed. U.S. National Library of Medicine.

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