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A preproenzyme is an enzyme with two additional characteriztics: "pre" refers to a signal sequence (signal peptide) which directs the enzyme to a specific organelle or subcellular localization; "pro" indicates that the enzyme is present in an inactive form and requires modification (e.g. cleavage) for activation.

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  • Braun P, de Groot A, Bitter W, Tommassen J. 1998. Secretion of elastinolytic enzymes and their propeptides by Pseudomonas aeruginosa. J Bacteriol. 1998; 180(13):3467-9. PMID 9642203