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Preprotachykinins are precursor proteins that are modified into tachykinin peptides. Via alternative slicing and post-translational modifications, preprotachykinins produce multiple peptide neurotransmitters.

There are two human preprotachykinins:[1]

  1. preprotachykinin-1 (also PPT-1, PPT-I, or PPT-A), which produces substance P and neurokinin A (also called "substance K"), and the derived neuropeptide K and neurokinin gamma.
  2. preprotachykinin-2 (also PPT-2, PPT-II, or PPT-B), which produces neurokinin B.


  1. ^ Helke CJ, Krause JE, Mantyh PW, Couture R, Bannon MJ (1 April 1990). "Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms". FASEB Journal. 4: 1606–15. PMID 1969374.