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- Primagen Holding BV, a biotech and pharmaceutical corporation in the Netherlands
- Primagen, a primordial alien monster, the primary antagonist and final boss of Turok 2: Seeds of Evil
- Primogen, the chief, and usually most powerful and eldest, representative of a vampire clan within a domain in Vampire: The Masquerade and Vampire: The Requiem
- Primogen Daishirou and Primogen Laenzuo, monsters in EverQuest II
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