|Preferred IUPAC name
PPACA; PPAA; T3P; Propylphosphonic anhydride
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||318.182 g·mol−1|
|P234, P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P390, P404, P405, P501|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Propanephosphonic acid anhydride (PPAA, T3P) is an anhydride of propanephosphonic acid. Its structure is a cyclic trimer, with a phosphorus–oxygen core and propyl groups and additional oxygens attached. The chemical is a useful reagent for peptide synthesis reactions, where it activates the carboxylic acid partner for subsequent reaction with amines. It is commercially available as 50 % solution in DMF or ethyl acetate as a slightly yellow mixture.