Proto-mitochondrion
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The proto-mitochondrion is the ancestral bacterial endosymbiont from which all mitochondria are thought to be derived.
Phylogeny
The phylogenetic analyses of the few genes that are still encoded in the genomes of modern mitochondria suggest an alpha-proteobacterial origin for this endosymbiont. Although the order Rickettsiales has been proposed as the alpha-proteobacterial sister-group of mitochondria, there is no definitive evidence as to from which alpha-proteobacterial group the proto-mitochondrion emerged.
| Schematic ribosomal RNA phylogeny of Alphaproteobacteria | ||||||||||||||||||||||||
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| The cladogram of Rickettsidae has been inferred by Ferla et al. [1] from the comparison of 16S + 23S ribosomal RNA sequences. |
Metabolism
Toni Gabaldón and Martijn Huynen (2003) reconstructed the proteome (the entire set of proteins expressed by a genome) and corresponding metabolism of the proto-mitochondrion by comparing extant alpha-proteobacterial and eukaryotic genomes. They concluded that this organism was an aerobic alpha-proteobacterium catabolyzing lipids, glycerol and other compounds provided by the host. At least 630 gene families derived from this organism can still be found in the 9 eukaryotic genomes analyzed in the study.[2]
See also
References
- ^ Ferla MP, Thrash JC, Giovannoni SJ, Patrick WM (2013). "New rRNA gene-based phylogenies of the Alphaproteobacteria provide perspective on major groups, mitochondrial ancestry and phylogenetic instability". PLOS ONE. 8 (12): e83383. Bibcode:2013PLoSO...883383F. doi:10.1371/journal.pone.0083383. PMC 3859672. PMID 24349502.
- ^ Gabaldón, T.; et al. (2003). "The proto-mitochondrial metabolism". Science. 301 (5633): 690. doi:10.1126/science.1085463. PMID 12893934.
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