RASSF1
Template:PBB Ras association domain-containing protein 1 is a protein that in humans is encoded by the RASSF1 gene.
Function
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[1]
Interactions
RASSF1 has been shown to interact with:
References
- ^ "Entrez Gene: RASSF1 Ras association (RalGDS/AF-6) domain family 1".
- ^ Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (Jul 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". The Journal of Biological Chemistry. 279 (28): 29247–54. doi:10.1074/jbc.M401699200. PMID 15075335.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Song MS, Song SJ, Kim SY, Oh HJ, Lim DS (Jul 2008). "The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex". The EMBO Journal. 27 (13): 1863–74. doi:10.1038/emboj.2008.115. PMC 2486425. PMID 18566590.
- ^ Vos MD, Ellis CA, Bell A, Birrer MJ, Clark GJ (Nov 2000). "Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis". The Journal of Biological Chemistry. 275 (46): 35669–72. doi:10.1074/jbc.C000463200. PMID 10998413.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ a b Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Research. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320.
- ^ Liu L, Vo A, McKeehan WL (Mar 2005). "Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5". Cancer Research. 65 (5): 1830–8. doi:10.1158/0008-5472.CAN-04-3896. PMID 15753381.
- ^ Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
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