RNA binding motif protein, Y-linked, family 1, member A1

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Protein RBMY1A1 PDB 2fy1.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases RBMY1A1, RBM, RBM1, RBM2, RBMY, RBMY1C, YRRM1, YRRM2, RNA binding motif protein, Y-linked, family 1, member A1
External IDs HomoloGene: 121598 GeneCards: RBMY1A1
Gene location (Human)
Y chromosome (human)
Chr. Y chromosome (human)[1]
Y chromosome (human)
Genomic location for RBMY1A1
Genomic location for RBMY1A1
Band Yq11.223 Start 21,511,372 bp[1]
End 21,549,326 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr Y: 21.51 – 21.55 Mb n/a
PubMed search [2] n/a
View/Edit Human

RNA-binding motif protein, Y chromosome, family 1 member A1/C is a protein that in humans is encoded by the RBMY1A1 gene.[3][4][5]

This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. Alternative splicing of transcripts results in two transcript variants that encode different proteins.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000234414 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Ma K, Inglis JD, Sharkey A, Bickmore WA, Hill RE, Prosser EJ, Speed RM, Thomson EJ, Jobling M, Taylor K, et al. (Jan 1994). "A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis". Cell. 75 (7): 1287–95. doi:10.1016/0092-8674(93)90616-X. PMID 8269511. 
  4. ^ Chai NN, Zhou H, Hernandez J, Najmabadi H, Bhasin S, Yen PH (Aug 1998). "Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene". Genomics. 49 (2): 283–9. doi:10.1006/geno.1998.5255. PMID 9598316. 
  5. ^ a b "Entrez Gene: RBMY1A1 RNA binding motif protein, Y-linked, family 1, member A1". 

Further reading[edit]