RNA polymerase V
RNA polymerase V is a multisubunit plant specific RNA polymerase found in nucleus. Together with RNA polymerase IV required for normal function and biogenesis of small interferring RNA (siRNA). Pol V is involved in siRNA-directed DNA methylation pathway which leads to heterochromatic silencing.[1]
RNA polymerase V is composed of 12 subunits that are paralogous to RNA polymerase II subunits. Two largest subunits (catalytic site) is the most conserved region sharing similarity with eukaryotic and bacterial polymerases.[2]
References
- ^ Wierzbicki A,Haag J and Pikaard CS (2008). Noncoding transcription by RNA Polymerase Pol IVb/Pol V mediates transcriptional silencing of overlapping and adjacent genes. Cell 135:635-648.
- ^ "Subunit compositions of the RNA-silencing enzymes Pol IV and Pol V reveal their origins as specialized forms of RNA polymerase II". http://www.ncbi.nlm.nih.gov. Retrieved 13 May 2015.
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