Jump to content

RNF111

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Yobot (talk | contribs) at 10:20, 2 August 2015 (WP:CHECKWIKI error fixes using AWB (11349)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Template:PBB E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene.[1][2]

Function

The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.[2]

Interactions

RNF111 has been shown to interact with Mothers against decapentaplegic homolog 7[3] and Mothers against decapentaplegic homolog 3.[3][4]

References

  1. ^ Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D (Apr 2001). "Induction of the mammalian node requires Arkadia function in the extraembryonic lineages". Nature. 410 (6830): 825–30. doi:10.1038/35071095. PMID 11298452.
  2. ^ a b "Entrez Gene: RNF111 ring finger protein 111".
  3. ^ a b Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, Ebina M, Nukiwa T, Miyazawa K, Imamura T, Miyazono K (Dec 2003). "Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7". The EMBO Journal. 22 (24): 6458–70. doi:10.1093/emboj/cdg632. PMC 291827. PMID 14657019.
  4. ^ Yuzawa H, Koinuma D, Maeda S, Yamamoto K, Miyazawa K, Imamura T (Jan 2009). "Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts". Bone. 44 (1): 53–60. doi:10.1016/j.bone.2008.09.013. PMID 18950738.

Further reading