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Ribosomal protein S5
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPS5 ; S5
External IDs OMIM603630 MGI1097682 HomoloGene783 GeneCards: RPS5 Gene
Species Human Mouse
Entrez 6193 20103
Ensembl ENSG00000083845 ENSMUSG00000012848
UniProt P46782 P97461
RefSeq (mRNA) NM_001009 NM_009095
RefSeq (protein) NP_001000 NP_033121
Location (UCSC) Chr 19:
58.39 – 58.39 Mb
Chr 7:
12.92 – 12.93 Mb
PubMed search [1] [2]

40S ribosomal protein S5 is a protein that in humans is encoded by the RPS5 gene.[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]


  1. ^ Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID 7772601. 
  2. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  3. ^ a b "Entrez Gene: RPS5 ribosomal protein S5". 

Further reading[edit]