Rindopepimut
Rindopepimut (CDX-110) is an injectable peptide cancer vaccine[1] which targets a mutant protein called EGFRvIII present in about 25% to 30% of glioblastoma cases.[2]
The vaccine consists of the EGFRv3-specific peptide (a 13-amino acid mutant vIII epitope[3]) conjugated to the non-specific immunomodulator keyhole limpet hemocyanin (KLH).[4]
The US FDA granted it Breakthrough Therapy Designation for glioblastoma in Feb 2015.[3]
Clinical trials
Glioblastoma
The phase II ACT III study reported encouraging results in June 2015.[1]
The ReACT clinical trial for glioblastoma reported encouraging results in 2015.[2]
In March 2016 the phase III ACT IV trial [5] was terminated because it did not increase overall survival.[6]
References
- ^ a b Zussman; et al. (2015). "Outcomes of the ACT III Study: Rindopepimut (CDX-110) Therapy for Glioblastoma". doi:10.1227/01.neu.0000465855.63458.0c.
{{cite journal}}: Cite journal requires|journal=(help) - ^ a b Celldex Vaccine Rindopepimut Cuts Death Risk From Brain Cancer, Study Shows. WSJ Nov 2015
- ^ a b FDA Grants Rindopepimut Breakthrough Designation for EGFRvIII-Positive Glioblastoma. Feb 2015
- ^ rindopepimut definition
- ^ Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma (ACT IV)
- ^ Rindopepimut Misses OS Endpoint in Phase III Glioblastoma Trial. March 2016
See also
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