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Ronald DePinho

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Ronald A. DePinho
Born1955 (age 68–69)
NationalityAmerican
CitizenshipU.S
Alma mater
Known forGenetic and biological mechanisms governing the development of cancer and driving the aging process and age-associated degenerative diseases.
SpouseLynda Chin
Children3
Scientific career
Institutions

Ronald A. DePinho (born 1955) is an American physician and research scientist. He served as president of MD Anderson Cancer Center from 2011 to 2017.[1] DePinho states that his concern for reducing the burden of cancer suffering became his life goal in 1998, when his father died of colon cancer.[2]

Early life and education

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DePinho was born in the Bronx, New York City in 1955 to Celeste and Alvaro DePinho. He is the third of five children. He earned a bachelor's degree in biological sciences in 1977 from Fordham University. He received his medical degree with distinction in microbiology and immunology in 1981 from Albert Einstein College of Medicine.[citation needed]

He completed an internship and residency in internal medicine at Columbia-Presbyterian Medical Center, followed by postdoctoral fellowships in the Department of Cell Biology at Albert Einstein College of Medicine and in the Department of Biochemistry and Biophysics at Columbia-Presbyterian Medical Center.[citation needed][3]

Career

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DePinho spent 14 years at Dana–Farber Cancer Institute. He served as founding director of the Belfer Institute for Applied Cancer Science and was an American Cancer Society Research Professor in the Department of Medicine (Genetics) at Harvard Medical School. Previously, he held several faculty positions during 10 years at Albert Einstein College of Medicine in New York, where he was the Betty and Sheldon Feinberg Senior Scholar in Cancer Research.[citation needed]

DePinho is Professor and former president in the Department of Cancer Biology at The University of Texas MD Anderson Cancer Center in Houston, Texas, and holds the Harry Graves Burkhart III Distinguished University Chair in Cancer Biology.[4] He assumed the presidency at MD Anderson on September 1, 2011. There, he founded the Institute for Applied Cancer Science to accelerate development of next-generation targeted immune- and cell-based cancer therapies. He launched MD Anderson's Cancer Moon Shots Program, which became a model for the White House Cancer Moonshot funded by President Barack Obama under the leadership of then-Vice President Joe Biden[5][6] and administered by National Cancer Institute.[7]

DePinho publicly announced his resignation as MD Anderson president on March 8, 2017, after scrutiny over the administration of the organization had put him in the spotlight. "DePinho's five-and-a-half years at the helm of the world's largest cancer center were marked by unprecedented turbulence, questions of conflicts of interest, and unhappiness on the part of the faculty."[8]  

Research

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DePinho is best known for his work on telomerase and telomere disfunction as it relates to cancer and aging. Specifically, in collaboration with Carol Greider, he generated the first telomerase knockout mouse.[9] This work led to a deeper understanding of telomerase and telomere dysfunction in cancer, aging and a range of degenerative diseases, including fibrosis.

DePinho's scientific program has made basic discoveries underlying cancer in the aged and factors governing acquired and inherited degenerative disorders. His laboratory established the concept of tumor maintenance, discovered a core pathway of aging and demonstrated that aging is a reversible process.[10] He has constructed and used refined mouse models of cancer to identify many new cancer targets and diagnostics.[citation needed]

He has published over 400 peer-reviewed research articles, review articles and book chapters (h-index 171).[11] He was inducted into the National Academy of Medicine in 2008,[12] the American Academy of Arts and Sciences in 2010,[13] the National Academy of Sciences in 2012,[14] and named an American Association for Cancer Research fellow in 2015.[15]

Honors

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Selected publications

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References

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  1. ^ "MD Anderson's Past Presidents". MD Anderson Cancer Center.
  2. ^ "Physician Scientist Devoted to Reduce Cancer Suffering". Ron DePinho.
  3. ^ "Ronald A. DePinho, M.D." National Foundation for Cancer Research. 2021-07-07.
  4. ^ "Ronald A. DePinho". MD Anderson Cancer Center.
  5. ^ Lowy, D; Singer, D; DePinho, R; Simon, GC; Soon-Shiong, P (9 June 2016). "Cancer moonshot countdown". Nature Biotechnology. 34 (6): 596–99. doi:10.1038/nbt.3616. PMC 6629023. PMID 27281415.
  6. ^ "The Vice President's Cancer Moonshot".
  7. ^ "Cancer Moonshot - National Cancer Institute". February 2016.
  8. ^ "DePinho resigns as MD Anderson president, acknowledges shortcomings as administrator". Cancer Letter. 9 March 2017.
  9. ^ Lee, HW; Blasco, MA; Gottlieb, GJ; Horner, JW; Greider, CW; DePinho, RA (April 1998). "Essential role of mouse telomerase in highly proliferative organs". Nature. 392 (6676): 569–74. Bibcode:1998Natur.392..569L. doi:10.1038/33345. PMID 9560153. S2CID 4385788.
  10. ^ "Partial reversal of aging achieved in mice". Harvard Gazette. 28 November 2010. Retrieved Sep 1, 2011.
  11. ^ "Ronald A. DePinho". Google Scholar.
  12. ^ "Ronald A. DePinho". National Academy of Medicine.
  13. ^ "Ronald Anthony DePinho". The American Academy of Arts & Sciences.
  14. ^ "Ronald A. DePinho". National Academy of Sciences.
  15. ^ "Ronald A. DePinho, MD | AACR | Fellows of the AACR".
  16. ^ "Cidadãos Estrangeiros Agraciados com Ordens Portuguesas". Página Oficial das Ordens Honoríficas Portuguesas. Retrieved 29 January 2017.
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