A Rosenthal fiber is a thick, elongated, worm-like or "corkscrew" eosinophilic (pink) bundle that is found on H&E staining of the brain in the presence of long-standing gliosis, occasional tumors, and some metabolic disorders.
Pilocytic astrocytoma is the most common primitive tumor in pediatric patients.
The fibers are found in astrocytic processes and are thought to be clumped intermediate filament proteins.
- Wippold FJ, Perry A, Lennerz J (May 2006). "Neuropathology for the neuroradiologist: Rosenthal fibers". AJNR Am J Neuroradiol. 27 (5): 958–61. PMID 16687524.
- Tanaka KF, Ochi N, Hayashi T, Ikeda E, Ikenaka K (October 2006). "Fluoro-Jade: new fluorescent marker of Rosenthal fibers". Neurosci. Lett. 407 (2): 127–30. doi:10.1016/j.neulet.2006.08.014. PMID 16949206.
- Neuropathology Mini-Course. Chapter 9 - Tumors of the Nervous System
- Doctor's Doctor - Brain and Spinal Cord
- Isolation of a major protein component of Rosenthal fibers
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