Rosenthal fiber

A Rosenthal fiber is a thick, elongated, worm-like or "corkscrew" eosinophilic (pink) bundle that is found on H&E staining of the brain in the presence of long-standing gliosis, occasional tumors, and some metabolic disorders.

Associated conditions

Its presence is associated with either pilocytic astrocytoma^[1] (more common) or Alexander's disease (a rare leukodystrophy). They are also seen in the context of fucosidosis.

Pilocytic astrocytoma is the most common primitive tumor in pediatric patients.

Composition

The fibers are found in astrocytic processes and are thought to be clumped intermediate filament proteins.

Their components include glial fibrillary acidic protein.^[2]

References

^ Wippold FJ, Perry A, Lennerz J (May 2006). "Neuropathology for the neuroradiologist: Rosenthal fibers". AJNR Am J Neuroradiol. 27 (5): 958–61. PMID 16687524.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Tanaka KF, Ochi N, Hayashi T, Ikeda E, Ikenaka K (October 2006). "Fluoro-Jade: new fluorescent marker of Rosenthal fibers". Neurosci. Lett. 407 (2): 127–30. doi:10.1016/j.neulet.2006.08.014. PMID 16949206.{{cite journal}}: CS1 maint: multiple names: authors list (link)

External links

Neuropathology Mini-Course. Chapter 9 - Tumors of the Nervous System
Doctor's Doctor - Brain and Spinal Cord
Isolation of a major protein component of Rosenthal fibers

This article related to pathology is a stub. You can help Wikipedia by expanding it.

[pmid16687524-1] Wippold FJ, Perry A, Lennerz J (May 2006). "Neuropathology for the neuroradiologist: Rosenthal fibers". AJNR Am J Neuroradiol. 27 (5): 958–61. PMID 16687524.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid16949206-2] Tanaka KF, Ochi N, Hayashi T, Ikeda E, Ikenaka K (October 2006). "Fluoro-Jade: new fluorescent marker of Rosenthal fibers". Neurosci. Lett. 407 (2): 127–30. doi:10.1016/j.neulet.2006.08.014. PMID 16949206.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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