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SKIP

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Template:PBB SKIP is an acronym for Skeletal muscle and kidney enriched inositol phosphatase, which is a human gene.[1]

Function

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[1] Overexpression of SKIP in mice affects osmoregulation in kidney collecting ducts.[2]

References

  1. ^ a b "Entrez Gene: SKIP skeletal muscle and kidney enriched inositol phosphatase".
  2. ^ Pernot E, Terryn S, Cheong SC, Markadieu N, Janas S, Blockmans M, Jacoby M, Pouillon V, Gayral S, Rossier BC, Beauwens R, Erneux C, Devuyst O, Schurmans S (Dec 2011). "The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system". Pflügers Archiv. 462 (6): 871–83. doi:10.1007/s00424-011-1028-0. PMID 21938401.

Further reading