SMSC may refer to:
- Seoul Metro (Seoul Metropolitan Subway Corporation)
- Shakopee Mdewakanton Sioux Community, a federally recognized tribe of Dakota people in Minnesota
- Short message service center
- Southwest Minnesota State College, now a university
- Spiritual, moral, social and cultural development, provided in schools through the National Curriculum for England.
- Standard Microsystems Corporation, a company acquired by Microchip Technology
- Smithsonian-Mason School of Conservation, a partnership between George Mason University and the Smithsonian Conservation Biology Institute
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