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SPX can refer to:
- S&P 500, a stock market index
- Sequenced packet exchange, part of the IPX/SPX protocol suite.
- IATA code of Sphinx International Airport, an airport in Giza, Egypt
- Small Press Expo, an alternative comics convention
- SpaceX (SpX), a rocket manufacturer
- Sports Performance eXtreme, a sports shoe and clothing brand
- SPX Corporation, a Fortune 500 electronics company
- St. Pius X, the 257th Pope of the Roman Catholic Church.
- Superphénix, a nuclear power plant
- A file extension used for Speex-encoded audio files
- The National Rail code for St Pancras International railway station in Greater London
- The former IATA and FAA code for Houston Gulf Airport
| disambiguation page lists articles associated with the title SPX.
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