STARD10
Template:PBB StAR-related lipid transfer protein 10 (STARD10) or PCTP-like protein is a lipid transfer protein that in humans is encoded by the STARD10 gene.[1][2] The protein derives its name from the fact that the molecule contains a START domain. As part of the StarD2 subfamily, StarD10 can transport the lipids phosphatidylcholine and phosphatidylethanolamine between membranes in solution.[3] Casein kinase II phosphorylates the protein on its serine at position 184.[4]
The function of StarD10 in the cell is not yet understood. Its expression is associated with cancer, but the nature of its role is unclear. Most recent data indicate that loss of StarD10 expression in breast cancer is associated with poor outcomes in patients.[5]
References
- ^ Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ (Jun 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int J Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: STARD10 START domain containing 10".
- ^ Olayioye MA, Vehring S, Müller P, Herrmann A, Schiller J, Thiele C, Lindeman GJ, Visvader JE, Pomorski T (Jul 2005). "StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein". J Biol Chem. 280 (29): 27436–42. doi:10.1074/jbc.M413330200. PMID 15911624.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Olayioye MA, Buchholz M, Schmid S, Schöffler P, Hoffmann P, Pomorski T (Aug 2007). "Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity". J Biol Chem. 282 (31): 22492–8. doi:10.1074/jbc.M701990200. PMID 17561512.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Murphy NC, Biankin AV, Millar EK, McNeil CM, O'Toole SA, Segara D, Crea P, Olayioye MA, Lee CS, Fox SB, Morey AL, Christie M, Musgrove EA, Daly RJ, Lindeman GJ, Henshall SM, Visvader JE, Sutherland RL (Mar 2010). "Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status". Int J Cancer. 126 (6): 1445–53. doi:10.1002/ijc.24826. PMID 19676041.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
Further reading
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