STK17A

STK17A
Identifiers
Aliases	STK17A, DRAK1, serine/threonine kinase 17a
External IDs	OMIM: 604726 HomoloGene: 55846 GeneCards: STK17A
Gene location (Human)
Chr.	Chromosome 7 (human)
End	43,650,713 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; blood; ; bone marrow; ; ganglionic eminence; ; vena cava; ; Achilles tendon; ; spleen; ; islet of Langerhans; ; bone marrow cells;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; ATP binding;
Cellular component	nucleus; plasma membrane; nuclear speck;
Biological process	positive regulation of apoptotic process; positive regulation of fibroblast apoptotic process; protein phosphorylation; intracellular signal transduction; regulation of reactive oxygen species metabolic process; phosphorylation; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	9263
	n/a
	ENSG00000164543
	n/a
	Q9UEE5
	n/a
	NM_004760
	n/a
	NP_004751
	n/a
	Wikidata
View/Edit Human

Serine/threonine kinase 17a is a protein that in humans is encoded by the STK17A gene.^[3]

Function[edit]

This gene is a member of the death-associated protein (DAP) kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.^[3]

In a recent study the gene (among others) shows a major role in centenarians longer lifespan.^[4]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164543 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Serine/threonine kinase 17a".
^ Garagnani P, Marquis J, Delledonne M, Pirazzini C, Marasco E, Kwiatkowska KM, et al. (May 2021). Tyler JK, Suh Y, Shuldiner AR (eds.). "Whole-genome sequencing analysis of semi-supercentenarians". eLife. 10: e57849. doi:10.7554/eLife.57849. PMC 8096429. PMID 33941312.

Further reading[edit]

Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, et al. (September 2009). "The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors". PLOS Genetics. 5 (9): e1000637. doi:10.1371/journal.pgen.1000637. PMC 2727793. PMID 19730683.
Sanjo H, Kawai T, Akira S (October 1998). "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis". The Journal of Biological Chemistry. 273 (44): 29066–71. doi:10.1074/jbc.273.44.29066. PMID 9786912.
Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, et al. (June 2011). "Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells". The Journal of Biological Chemistry. 286 (22): 19381–91. doi:10.1074/jbc.M111.218040. PMC 3103316. PMID 21489989.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164543 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Serine/threonine kinase 17a".

[4] Garagnani P, Marquis J, Delledonne M, Pirazzini C, Marasco E, Kwiatkowska KM, et al. (May 2021). Tyler JK, Suh Y, Shuldiner AR (eds.). "Whole-genome sequencing analysis of semi-supercentenarians". eLife. 10: e57849. doi:10.7554/eLife.57849. PMC 8096429. PMID 33941312.

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