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Sainte-Reine may refer to:
- Saint Regina (martyr), early Christian martyr of France
- Sainte-Reine, Haute-Saône, a commune in the French region of Franche-Comté
- Sainte-Reine, Savoie, a commune in the French region of Rhône-Alpes
| disambiguation page lists articles about distinct geographical locations with the same name.
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