Satratoxin-H

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Satratoxin-H
Satratoxin-H.svg
Names
IUPAC name
(2'R,4E,9R,10E,12Z,16R,16aS,18R,19aR,23aR,25R)-6,7,16,16a,19a,22-

hexahydro-25-hydroxy-9-((1S)-1-hydroxyethyl)-16a,21-dimethyl-spiro(5,9,16,18-dimethano- 1H,3H,23H-(1,6,12)trioxacyclooctadecino(3,4-d)(1)benzopyran-17(18H)-2'-oxirane)-

3,14(9H)-dione
Identifiers
3D model (JSmol)
ChemSpider
Properties
C29H36O9
Molar mass 528.591
insoluble
Hazards
Main hazards Toxic
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Satratoxin-H, a trichothecene mycotoxin, is a naturally occurring toxin produced by the ascomycetes Stachybotrys chartarum and Podostroma cornu-damae which is toxic to humans and animals. The clinical condition it causes is known as Stachybotrotoxicosis. It is related to the mycotoxin T-2, but unlike T-2 has not been reported to have been used as a biological weapon.

Properties[edit]

Satratoxin-H is almost completely insoluble in water, but is easily soluble in lower alcohols and polar solvents such as ethanol, methanol, 2-propanol, acetone and chloroform.[1]

Satratoxin-H is not officially classified as a chemical weapon.[citation needed]

Effects[edit]

Satratoxin-H is extremely versatile. Contact with the solution through ingestion, inhalation, or even physical contact produces symptoms similar to those listed below.

  • a rash that becomes a moist dermatitis
  • nosebleeds
  • chest pain
  • pulmonary hemorrhage (bleeding in the lungs)
  • hyperthermia (raised temperature)
  • headache
  • fatigue

However, if consumed in large quantities, it can be lethal. Satratoxin-H has little effect on bare skin, and does not blister in the way many chemical weapons do. However, upon sensitive surfaces (eyes, interior of mouth or nose), it can irritate the skin or cause a rash.

The toxicology of satratoxin-H shows that it has an LD50 for mice of 1.0-1.4 mg/kg, upon injection. Otherwise it is reported to be about five times as toxic as the T-2 toxin.[2]

References[edit]

  • Croft, W. A.; Jarvis, B. B.; Yatawara, C. S. (1986). "Airborne outbreak of trichothecene toxicosis". Atmospheric Environment. 20 (3): 549–552. doi:10.1016/0004-6981(86)90096-X. 
  • Nikulin, M.; Reijula, K.; Jarvis, B. B.; Veijalainen, P.; Hintikka, E. L. (1997). "Effects of Intranasal Exposure to Spores of Stachybotrys atra in Mice". Fundamental and Applied Toxicology. 35 (2): 182–188. PMID 9038239. doi:10.1093/toxsci/35.2.182.