This article may be too technical for most readers to understand. Please help improve it to make it understandable to non-experts, without removing the technical details. (February 2015) (Learn how and when to remove this template message)
Sca-1 stands for "Stem cells antigen-1". It consist of 18-kDa mouse glycosyl phosphatidylinositol-anchored cell surface protein (GPI-AP) of the LY6 gene family. It is the common biological marker used to identify hematopoitic stem cell (HSC) along with other markers.
Application of Sca-1
- Sca-1 has a regenerative role in cardiac repair: Host cells with specific Sca-1+CD31− markers arise upon myocardial infarction, with evidence of expression of Sca-1 protein.
- Sca-1 plays a role in hematopoietic progenitor/stem cell lineage fate and c-kit expression.
- "Concise Review: Stem Cell Antigen-1: Expression, Function, and Enigma".
- Wang, X; Hu, Q; Nakamura, Y; Lee, J; Zhang, G; From, AH; Zhang, J. "The role of the sca-1+/CD31- cardiac progenitor cell population in postinfarction left ventricular remodeling". Stem Cells. 24: 1779–1788. doi:10.1634/stemcells.2005-0386. PMID 16614004.
- Bradfute, SB; Graubert, TA; Goodell, MA (2005). "Roles of Sca-1 in hematopoietic stem/progenitor cell function". Exp. Hematol. 33: 836–43. doi:10.1016/j.exphem.2005.04.001. PMID 15963860.
|This cell biology article is a stub. You can help Wikipedia by expanding it.|
|This protein-related article is a stub. You can help Wikipedia by expanding it.|