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The Caenorhabditis elegans sel-12 gene encodes a multi-pass transmembrane domain protein that is similar to human presenilin.[1] sel-12 positively regulates the lin-12 and glp-1 Notch signaling pathways during hermaphrodite gonadal, vulval, and germline development.[1] sel-12 also plays a role in thermotaxis (the nematode worm prefers a certain temperature and moves accordingly).[2]

C. elegans gene abbreviations: sel, Suppressor/Enhancer of Lin-12; lin, cell LINeage defective; glp, Germ Line Proliferation defective.

External links[edit]

sel-12 gene summary (WormBase)


  1. ^ a b Diane Levitan, Iva Greenwald (September 1995). "Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene". Nature. 377 (6547): 351–354. doi:10.1038/377351a0. PMID 7566091. 
  2. ^ Stefan Eimer (2003). "Analysis and suppression of mutant sel-12 in C. elegans". Ph.D. Thesis, Ludwig-Maximilians Universität, Munich, Germany.