Sereny test

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The Sereny test is a test used to test the invasiveness of organisms such as entero invasive Escherichia coli.[1][2]

It is also used on Listeria monocytogenes.[3]

It is done by inoculating suspension of bacteria into guinea pig's eye. Severe mucopurulent conjunctivitis and severe keratitis indicates a positive test.


  • Ananthanarayan et al., Paniker et al.; Textbook of Microbiology; 8th Edition; 2009; 277; Universities Press; India
  1. ^ Wood PK, Morris JG, Small PL, et al. (September 1986). "Comparison of DNA probes and the Sereny test for identification of invasive Shigella and Escherichia coli strains". J. Clin. Microbiol. 24 (3): 498–500. PMC 268950free to read. PMID 3531233. 
  2. ^ Murayama SY, Sakai T, Makino S, Kurata T, Sasakawa C, Yoshikawa M (February 1986). "The use of mice in the Sereny test as a virulence assay of shigellae and enteroinvasive Escherichia coli". Infect. Immun. 51 (2): 696–8. PMC 262412free to read. PMID 3510985. 
  3. ^ "Sereny test" at Dorland's Medical Dictionary[dead link]