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Sergey Piletsky

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Sergey Piletsky
NationalityBritish
EducationPhD, DSc
Alma mater Kyiv University, Cranfield University
OccupationProfessor
EmployerLeicester University
Known for
  • Biosensors
  • Molecularly imprinted polymers
  • Computational design of molecular imprinting
AwardsRoyal Society Wolfson Research Merit Award

Leverhulme Trust Fellowship

DFG Fellowship Institute of Analytical Chemistry

Award of President of Ukraine

Japan Society for Promotion of Science and Technology Fellowship
Websitehttps://le.ac.uk/people/sergey-piletsky

Sergey Piletsky is a professor of Bioanalytical Chemistry and the Research Director for School of Chemistry, University of Leicester, United Kingdom.[1]

Education

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Sergey graduated from Kyiv University, Ukraine, obtaining an MSc in chemistry in 1985 and researched on synthesis of the polymers selective for nucleic acids, for which he was awarded with a PhD in 1991. Cranfield University awarded Sergey with a DSc for his work on molecularly imprinted polymers for diagnostics applications.[1]

Awards

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Sergey is a recipient of Royal Society Wolfson Research Merit Award,[1] Leverhulme Trust Fellowship, DFG Fellowship from the Institute of Analytical Chemistry, Award of President of Ukraine, and Japan Society for Promotion of Science and Technology Fellowship.[1]

Research

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Sergey's work in molecular imprinting focuses on: (i) the fundamental study of the recognition properties of molecularly imprinted polymers;[2][3] (ii) the development of sensors and assays for environmental and clinical analysis;[4] and (iii) the development of molecularly imprinted polymer nanoparticles for theranostic applications.[5]

Sergey introduced computational design into the field of molecular imprinting, by scientifically demonstrating that non-covalent interaction between the template molecule and polymer is through the technique known as 'bite and switch' wherein functional groups first non-covalently bond with the binding site, but during the rebinding step, the polymer matrix forms irreversible covalent bonds with the target molecule.[6] A number of research groups around the world follow his ideas in developing functional imprinted polymers for a variety of applications.[7][8]

Notable publications

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  • Turner, Nicholas W.; Subrahmanyam, Sreenath; Piletsky, Sergey A. (2009-01-26). "Analytical methods for determination of mycotoxins: A review". Analytica Chimica Acta. 632 (2): 168–180. Bibcode:2009AcAC..632..168T. doi:10.1016/j.aca.2008.11.010. ISSN 0003-2670. PMID 19110091.
  • Whitcombe, Michael J.; Chianella, Iva; Larcombe, Lee; Piletsky, Sergey A.; Noble, James; Porter, Robert; Horgan, Adrian (2011-02-22). "The rational development of molecularly imprinted polymer-based sensors for protein detection". Chemical Society Reviews. 40 (3): 1547–1571. doi:10.1039/C0CS00049C. hdl:1826/6232. ISSN 1460-4744. PMID 21132204.
  • Bossi, A.; Bonini, F.; Turner, A. P. F.; Piletsky, S. A. (2007-01-15). "Molecularly imprinted polymers for the recognition of proteins: The state of the art". Biosensors and Bioelectronics. 22 (6): 1131–1137. doi:10.1016/j.bios.2006.06.023. ISSN 0956-5663. PMID 16891110.
  • Surface-grafted molecularly imprinted polymers for protein recognition, A Bossi, SA Piletsky, EV Piletska, PG Righetti, APF Turner, Analytical chemistry 73 (21), 5281-5286[9]
  • Electrochemical sensor for catechol and dopamine based on a catalytic molecularly imprinted polymer-conducting polymer hybrid recognition element, Dhana Lakshmi, Alessandra Bossi, Michael J Whitcombe, Iva Chianella, Steven A Fowler, Sreenath Subrahmanyam, Elena V Piletska, Sergey A Piletsky, Analytical Chemistry 81 (9), 3576-3584[10]
  • Subrahmanyam, Sreenath; Karim, Kal; Piletsky, Sergey A. (2012), Piletsky, Sergey A.; Whitcombe, Michael J. (eds.), "Computational Approaches in the Design of Synthetic Receptors", Designing Receptors for the Next Generation of Biosensors, vol. 12, Berlin, Heidelberg: Springer Berlin Heidelberg, pp. 131–165, doi:10.1007/5346_2012_22, ISBN 978-3-642-32328-7, retrieved 2022-08-17
  • Subrahmanyam, Sreenath; Piletsky, Sergey A. (2009), "Computational Design of Molecularly Imprinted Polymers", Combinatorial Methods for Chemical and Biological Sensors, New York, NY: Springer New York, pp. 135–172, Bibcode:2009cmcb.book..135S, doi:10.1007/978-0-387-73713-3_6, ISBN 978-0-387-73712-6, retrieved 2022-08-16
  • Poma, Alessandro; Whitcombe, Michael; Piletsky, Sergey (2012), "Plastic Antibodies", Springer Series on Chemical Sensors and Biosensors, Berlin, Heidelberg: Springer Berlin Heidelberg, pp. 105–129, doi:10.1007/5346_2012_24, ISBN 978-3-642-32328-7, retrieved 2022-08-16
  • Rouillon, Régis; Piletsky, Sergey A.; Breton, Florent; Piletska, Elena V.; Carpentier, Robert (2006), Giardi, Maria Teresa; Piletska, Elena V. (eds.), "Photosystem II Biosensors for Heavy Metals Monitoring", Biotechnological Applications of Photosynthetic Proteins: Biochips, Biosensors and Biodevices, Biotechnology Intelligence Unit, Boston, MA: Springer US, pp. 166–174, doi:10.1007/978-0-387-36672-2_15, ISBN 978-0-387-36672-2, retrieved 2022-08-17
  • Piletsky S.A., Turner A.P.F. (2006). New generation of chemical sensors based on molecularly imprinted polymers, in: Molecular imprinting of polymers, S. Piletsky and A.P.F. Turner (eds.), Landes Bioscience, Georgetown, TX, USA[11]

Notable patents

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  • Rationally Designed Selective Binding Polymers (2010), Publication number: 20100009859, Inventors: Sergey A. Piletsky, Olena Piletska, Khalku Karim, Coulton H. Legge, Sreenath Subrahmanyam[12]
  • Electrochemical Sensor (2019) Publication number: 20210239643, Inventors: Sergey Piletsky, Omar Sheej Ahamad, Alvaro Garcia Cruz[13]
  • Polymerisation method, polymers and uses thereof (2006) Publication number: 20060122288, Inventors: Sergey Piletsky, Olena Piletska, Anthony Turner, Khalku Karim, Beining Chen[14]
  • Methods and Kits for determining binding sites (2020) Publication number: 20200033356, Inventors: Sergey Piletsky, Elena Piletska, Francesco Canfarotta, Don Jones[15]
  • Photoreactor and Process for Preparing MIP Nanoparticles (2014) Publication number: 20140228472, Inventors: Sergey Piletsky, Olena Piletska, Antonio Guerreiro, Michael Whitcombe, Alessandro Poma[16]

References

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  1. ^ a b c d "Sergey Piletsky | People | University of Leicester". le.ac.uk. Retrieved 2022-08-16.
  2. ^ Piletsky, Sergey A.; Andersson, Håkan S.; Nicholls, Ian A. (1998). "The rational use of hydrophobic effect-based recognition in molecularly imprinted polymers". Journal of Molecular Recognition. 11 (1–6): 94–97. doi:10.1002/(sici)1099-1352(199812)11:1/6<94::aid-jmr398>3.0.co;2-c. PMID 10076815. S2CID 32111375.
  3. ^ Andersson, Håkan S; Karlsson, Jesper G; Piletsky, Sergey A; Koch-Schmidt, Ann-Christin; Mosbach, Klaus; Nicholls, Ian A (1999). "Study of the nature of recognition in molecularly imprinted polymers, II". Journal of Chromatography A. 848 (1–2): 39–49. doi:10.1016/s0021-9673(99)00483-5. ISSN 0021-9673.
  4. ^ Piletsky, Sergey A.; Subrahmanyam, S.; Turner, Anthony P.F. (2001-12-01). "Application of molecularly imprinted polymers in sensors for the environment and biotechnology". Sensor Review. 21 (4): 292–296. doi:10.1108/eum0000000005998. ISSN 0260-2288.
  5. ^ Corrigan, Damion K; Salton, Neale A; Preston, Chris; Piletsky, Sergey (2010-08-02). "Towards the development of a rapid, portable, surface enhanced Raman spectroscopy based cleaning verification system for the drug nelarabine". Journal of Pharmacy and Pharmacology. 62 (9): 1195–1200. doi:10.1111/j.2042-7158.2010.01152.x. ISSN 0022-3573. PMID 20796200. S2CID 37284684.
  6. ^ Subrahmanyam, Sreenath; Piletsky, Sergey A; Piletska, Elena V; Chen, Beining; Karim, Kal; Turner, Anthony P.F (2001). "'Bite-and-Switch' approach using computationally designed molecularly imprinted polymers for sensing of creatinine11Editors Selection". Biosensors and Bioelectronics. 16 (9–12): 631–637. doi:10.1016/s0956-5663(01)00191-9. ISSN 0956-5663. PMID 11679238.
  7. ^ Marć, Mariusz; Kupka, Teobald; Wieczorek, Piotr Paweł; Namieśnik, Jacek (2018). "Computational modeling of molecularly imprinted polymers as a green approach to the development of novel analytical sorbents". TrAC Trends in Analytical Chemistry. 98: 64–78. doi:10.1016/j.trac.2017.10.020. ISSN 0165-9936.
  8. ^ Reyes, N B D; Pajarito, B B (2019-10-01). "Computational design of dummy molecularly imprinted polymers via hydrogen bonding investigation for oxytetracycline determination". IOP Conference Series: Materials Science and Engineering. 634 (1): 012035. Bibcode:2019MS&E..634a2035R. doi:10.1088/1757-899x/634/1/012035. ISSN 1757-8981. S2CID 210806505.
  9. ^ Bossi, Alessandra; Piletsky, Sergey A.; Piletska, Elena V.; Righetti, Pier Giorgio; Turner, Anthony P. F. (2001-11-01). "Surface-Grafted Molecularly Imprinted Polymers for Protein Recognition". Analytical Chemistry. 73 (21): 5281–5286. doi:10.1021/ac0006526. ISSN 0003-2700. PMID 11721930.
  10. ^ Lakshmi, Dhana; Bossi, Alessandra; Whitcombe, Michael J.; Chianella, Iva; Fowler, Steven A.; Subrahmanyam, Sreenath; Piletska, Elena V.; Piletsky, Sergey A. (2009-05-01). "Electrochemical Sensor for Catechol and Dopamine Based on a Catalytic Molecularly Imprinted Polymer-Conducting Polymer Hybrid Recognition Element". Analytical Chemistry. 81 (9): 3576–3584. doi:10.1021/ac802536p. ISSN 0003-2700. PMID 19354259.
  11. ^ F., Piletsky, Sergey. Turner, Anthony P. (2006). Molecular imprinting of polymers. Landes Bioscience. ISBN 1-58706-219-4. OCLC 65195271.{{cite book}}: CS1 maint: multiple names: authors list (link)
  12. ^ "US Patent Application for RATIONALLY DESIGNED SELECTIVE BINDING POLYMERS Patent Application (Application #20100009859 issued January 14, 2010) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
  13. ^ "US Patent Application for ELECTROCHEMICAL SENSOR Patent Application (Application #20210239643 issued August 5, 2021) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
  14. ^ "US Patent Application for Polymerisation method, polymers and uses thereof Patent Application (Application #20060122288 issued June 8, 2006) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
  15. ^ "US Patent Application for METHODS AND KITS FOR DETERMINING BINDING SITES Patent Application (Application #20200033356 issued January 30, 2020) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
  16. ^ "US Patent Application for Photoreactor and Process for Preparing MIP Nanoparticles Patent Application (Application #20140228472 issued August 14, 2014) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
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