Serratiopeptidase: Difference between revisions
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Closed because of bias, wrong information and someone keeps changing my edits please contact robert4goodhealth at yahoo dot com |
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'''Serratiopeptidase''' (also known as '''serratiapeptase''', '''serratia peptidase''', '''serratio peptidase''', or '''serrapeptidase''') is a proteolytic [[enzyme]] isolated from the non-pathogenic [[enterobacteria]] Serratia E15 found in [[silkworms]]. It has a history of use in Japan and Europe in [[alternative medicine]] for pain and inflammation,<ref>{{cite web |url=http://www.reference.md/files/C022/mC022640.html |title=Serratiopeptidase (definition) |accessdate=2008-03-20 |format=HTML |work=Reference.MD}}</ref> but there is no convincing evidence backing this use.<ref name="Bandolier" /> |
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Serratiopeptidase formulations are available over-the-counter in the United States and most other countries. |
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== Studies == |
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A [[systematic review]] by the [[evidence-based healthcare]] [[medical journal]] [[Bandolier (journal)|Bandolier]] stated that "[t]he evidence on serratiopeptidase being effective for anything is not based on a firm foundation of clinical trials."<ref name="Bandolier">{{cite web |url=http://www.jr2.ox.ac.uk/bandolier/booth/alternat/serrapep.html |title=Serratiopeptidase: Finding the Evidence |accessdate=2008-03-20 |format=HTML |work=Bandolier online edition}}</ref> |
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The review revealed only 34 total publications in medical databases that addressed the efficacy of seratiopeptidase, of which several were found to be animal experiments, personal letters, uncontrolled trials or those with inadequate or nonexistent randomisation. Several of the case reports also indicated adverse reactions to the enzyme without mentioning so in the abstract.<ref name="Bandolier"/> |
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Contrary to anecdotal reports, no studies were found to have ever been conducted on the efficacy of serratiopeptidase as treatment for back pain, heart attack, stroke, or asthma. Of the 10 medical conditions with randomized-evidence studies on file in connection with serratiopeptidase, trial quality was described as "generally poor". According to Bandolier: {{Quote box |
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| quote = "Studies were small, outcomes were poorly defined, and in some, different medical conditions were mixed. Five studies were described as double blind: one was completely uninterpretable, three methodologically weak studies were positive, and one trial of apparent high quality was negative. This latter study compared serratiopeptidase, serraprose S or placebo in the treatment of chronic respiratory disease, with about 120 patients per group, and found no significant difference between groups for any outcome." |
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| source = - [[Bandolier (journal)|Bandolier]], ''"Serratiopeptidase - Finding the Evidence"'' <ref name="Bandolier"/> |
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== References == |
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{{reflist}} |
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[[Category:Biologically based therapies]] |
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Revision as of 14:59, 24 April 2009
Closed because of bias, wrong information and someone keeps changing my edits please contact robert4goodhealth at yahoo dot com