"Set It Off" was written by Timomatic and DNA Songs, who also produced the song. Speaking of the song, Timomatic said: "In a global sense, the first thing I want people to know about me as an artist is 'Set It Off'. It shows off my energy and my musical style, and the video shows just how much I love to dance. I really believe that 'Set It Off' is the first official sound of Timomatic – it's the closest I've ever come to finding a perfect representation of me." He stated that the song is "about having fun on the dance floor and loving life."
"Set It Off" was released digitally on 18 November 2011. An extended play, featuring two remixes of "Set It Off", as well as an additional track, was released as a CD on 2 December 2011. The extended play was released digitally on 9 December 2011.
The music video for "Set It Off" premiered online on 18 November 2011. Many scenes throughout the video are intercut. The video opens with Timomatic arriving at a bar dressed in a blue, red and white shirt, blue jeans, red cap and sneakers. He then starts to play the song and freestyle dances to it. During the first chorus, the video cuts to Timomatic performing on stage in front of a black backdrop, dressed in a black leather jacket, jeans and shades. Intercut scenes of Timomatic dancing in the green room of the bar are then shown. The video then cuts back to the bar scenes, where Timomatic and his two male dancers perform choreography. Intercut scenes of Timomatic dancing on the staircase are then shown. On 6 January 2012, Timomatic performed "Set It Off" on Sunrise. He also performed the song at Miss Universe 2012 in Las Vegas.