Osborne was born in British Columbia. She studied opera performance at the University of British Columbia and later joined the Canadian Opera Company's Studio Ensemble program. Prior to joining the COC, she busked on the streets of Toronto in order to be able to afford singing lessons.
She is "considered one of Canada's most sought-after sopranos". She sings with the Canadian Opera Company and has also appeared with ensembles from around the world, including the New York City Opera, the Vancouver Symphony, and the Los Angeles Philharmonic. Her operatic roles have included Susanna in Le nozze di Figaro, Gilda in Rigoletto, and Pamina in Die Zauberflöte. One of her performances of Pamina, with the Vancouver Opera, required her to learn an English and Musqueam adaptation. She also participated in the Viva Verdi! gala in Zurich in celebration of Giuseppe Verdi's bicentennial.
Osborne has received significant critical recognition. F. Paul Driscol of Opera News called her a "lyric soprano with outstanding ability and impressive charm". Marilyn Horne, who Osborne cites as a mentor, said Osborne is "half athlete and half artist...She understands that voices need to be brilliant, dark and bright, all at once". Osborne was the first winner of the Jeunesses Musicales Canada's Maureen Forrester Award Tour, which comprises two seasons of recitals across Canada and a commission from the Canadian Art Song Project. Osborne has also won the Marilyn Horne Foundation Competition and the International Czech and Slovak Opera Competition.
- Iannacci, Elio (2 February 2014). "From street singer to star soprano". Maclean's.
- Duke, David Gordon (28 December 2012). "Rising opera star Simone Osborne talks strives for balance amid stardom". Vancouver Sun.
- Crawford, Trish (12 November 2013). "Soprano Simone Osborne leaps to opera's big leagues". Toronto Star.
- "Simone Osborne". Columbia Artists. Retrieved 10 March 2014.
- "Soprano Simone Osborne wins Jeunesses Musicales first Maureen Forrester Award". Musical Toronto. 30 November 2012.