Sisto can refer to:
- San Sisto, "Saint Sixtus", dedication of several Italian churches
- Sisto, character on The Brak Show
- Jeremy Sisto, American actor
- José Sisto, Spanish politician, Governor of Guam
- Pione Sisto, Ugandan-born Danish footballer of South Sudanese origin
- Rocco Sisto, American actor
|This disambiguation page lists articles associated with the title Sisto.
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