Slippery sequence

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A slippery sequence is a small section of codon nucleotide sequences (usually UUUAAAC) that controls the rate of ribosomal frameshifting. A slippery sequence causes a faster ribosomal transfer which in turn can cause the reading ribosome to "slip." This allows a tRNA to shift by 1 base after it has paired with its anticodon, changing the reading frame.[1][2][3][4][5]

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  1. ^ Green L, Kim CH, Bustamante C, Tinoco I Jr. "Characterization of the Mechanical Unfolding of RNA Pseudoknots." J Mol Biol. 26 May 2007
  2. ^ Chien-Hung Yu, Mathieu H. M. Noteborn and René C. L. Olsthoorn.Stimulation of ribosomal frameshifting by antisense LNA. Nucl.Acids Res (2010) 38 (22):8277-8238
  3. ^
  4. ^ "Molecular Biology: Frameshifting occurs at slippery sequences". Retrieved 2013-07-28. 
  5. ^ Farabaugh, P. J.; Björk, G. R. (15 March 1999). "How translational accuracy influences reading frame maintenance". EMBO J. 18 (6): 1427–1434. doi:10.1093/emboj/18.6.1427. PMC 1171232Freely accessible. PMID 10075915 – via PubMed. 

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