A slippery sequence is a small section of codon nucleotide sequences (usually UUUAAAC) that controls the rate of ribosomal frameshifting. A slippery sequence causes a faster ribosomal transfer which in turn can cause the reading ribosome to "slip." This allows a tRNA to shift by 1 base after it has paired with its anticodon, changing the reading frame.
- Ribosomal frameshifting
- Open reading frame
- Translational frameshift
- Nucleic acid tertiary structure
- Transposable element
- Green L, Kim CH, Bustamante C, Tinoco I Jr. "Characterization of the Mechanical Unfolding of RNA Pseudoknots." J Mol Biol. 26 May 2007
- Chien-Hung Yu, Mathieu H. M. Noteborn and René C. L. Olsthoorn.Stimulation of ribosomal frameshifting by antisense LNA. Nucl.Acids Res (2010) 38 (22):8277-8238
- "Molecular Biology: Frameshifting occurs at slippery sequences". Molecularstudy.blogspot.com. Retrieved 2013-07-28.
- Frameshifting, Ribosomal at the US National Library of Medicine Medical Subject Headings (MeSH)
- Wise2 - aligns a protein against a DNA sequence allowing frameshifts and introns
- FastY - compare a DNA sequence to a protein sequence database, allowing gaps and frameshifts
- Path - tool that compares two frameshift proteins (back-translation principle)
- Recode2 - Database of recoded genes, including those that require programmed Translational frameshift.
|This molecular or cell biology article is a stub. You can help Wikipedia by expanding it.|