Small multidrug resistance protein
| Small Multidrug Resistance protein | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbol | Multi_Drug_Res | ||||||||||
| Pfam | PF00893 | ||||||||||
| InterPro | IPR000390 | ||||||||||
| SCOP2 | 1s7b / SCOPe / SUPFAM | ||||||||||
| TCDB | 2.A.7 | ||||||||||
| OPM protein | 2f2m | ||||||||||
| |||||||||||
Small multidrug resistance protein is a family of integral membrane proteins which confer drug resistance to a wide range of toxic compounds by removing them for the cells. The efflux is coupled to an influx of protons. An example is Escherichia coli mvrC P23895 which prevents the incorporation of methyl viologen into cells[1] and is involved in ethidium bromide efflux.[2]
References
- ^ Morimyo M, Hongo E, Hama-inaba H, Machida I (1992). "Cloning and characterization of the mvrC gene of Escherichia coli K-12 which confers resistance against methyl viologen toxicity". Nucleic Acids Res. 20 (12): 3159–3165. doi:10.1093/nar/20.12.3159. PMC 312453. PMID 1320256.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Purewal AS (1991). "Nucleotide sequence of the ethidium efflux gene from Escherichia coli". FEMS Microbiol. Lett. 66 (2): 229–231. doi:10.1111/j.1574-6968.1991.tb04870.x. PMID 1936950.
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