Solubilization is the process of incorporating the solubilizate (the component that undergoes solublization) into or onto the micelles. Solublization may occur in a system consisting of a solvent, an association colloid (a colloid that forms micelles), and at least one other solubilizate.
Usage of the term
Solubilization is distinct from dissolution because the resulting fluid is a colloidal dispersion involving an association colloid. This suspension is distinct from a true solution, and the amount of the solubilizate in the micellar system can be different (often higher) than the regular solubility of the solubilizate in the solvent.
In non-chemical literature and in everyday language, the term "solubilization" is sometimes used in a broader meaning as "to bring to a solution or (non-sedimenting) suspension" by any means, e.g., leaching by a reaction with an acid.
Micellar solublization is widely utilized, e.g. in:
- laundry washing using detergents,
- in pharmaceutical industry, for formulations of poorly soluble drugs in solution form,
- in cleanup of oil spills using dispersants.
Literature distinguishes two major mechanisms of solubilization process of oil by surfactant micelles, affecting the kinetics of solubilization:
- Surface reaction, i.e., by transient adsorption of micelles at the water-oil interface, and
- bulk reaction, whereby the surfactant micelles capture dissolved oil molecules.
- Micellar solublization. In: International Union of Pure and Applied Chemistry, "Compendium of Chemical Terminology" ("the Gold Book"), 2nd edition. Blackwell Scientific Publications, Oxford, 1997. (2006-)
- Jain A, Ran Y, Yalkowsky S, "Effect of pH-Sodium Lauryl Sulfate Combination on Solubilization of PG-300995 (an Anti-HIV Agent): A Technical Note." AAPS PharmSciTech. 2004; 5(3): article 45. 
- P. D. Todorov, P. A. Kralchevsky, N. D. Denkov, G. Broze, and A. Mehreteab, "Kinetics of Solubilization of n-Decane and Benzene by Micellar Solutions of Sodium Dodecyl Sulfate". Journal of Colloid and Interface Science 245, 371–382 (2002), doi:10.1006/jcis.2001.8031 
|Look up solubilization or solubilizate in Wiktionary, the free dictionary.|