Spuyten Duyvil may refer to:
- Spuyten Duyvil Creek, a channel connecting the Hudson River to the Harlem River Ship Canal, and on to the Harlem River in New York City
- Spuyten Duyvil (Metro-North station), a commuter railroad station that serves the residents of the Spuyten Duyvil neighborhood of the Bronx, New York via the Hudson Line
- Spuyten Duyvil, Bronx, the name of a subsection of the Riverdale section in New York City
- Spuyten Duyvil Bridge, a swing bridge that carries Amtrak's Empire Corridor line across the Spuyten Duyvil Creek between Manhattan and the Bronx, in New York City
- Spuyten Duyvil derailment, a commuter train accident which occurred near Spuyten Duyvil station.
- Spuyten Duyvil and Port Morris Railroad, a precursor railway to the New York Central Railroad
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