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St Columb may refer to:
- Columba or St Columb of Scotland
- St Columb's Cathedral, Derry, Northern Ireland
- St Columb's College, Derry, Northern Ireland
- Saint Columba the Virgin or St Columb of Cornwall
- St Columb Canal, in Cornwall, England
- St Columb Major, town in Cornwall, England
- St Columb Minor, village in Cornwall, England
- St Columb Road, village in Cornwall, England
- Lady Dona St Columb, a character in Frenchman's Creek by Daphne du Maurier
- The Monastery of St Columb, a book by Regina Maria Roche
|This disambiguation page lists articles associated with the title St Columb.
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