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St. Luke's may refer to:
- St Luke's, Islington, a district of London, UK
- St Luke's, Old Street, church of the above parish
- St. Luke's Campus, part of the University of Exeter, Exeter, Devon, England
- St Luke's railway station, Southport, Merseyside, UK
- St. Luke's Health Network, a hospital/health network in Bethlehem, Pennsylvania, USA
- Saint Luke's Health System, a health care system and affiliated hospitals around Kansas City, Missouri, USA
- Saint Luke's Home for Destitute and Aged Women in Middletown, Connecticut, USA
- St. Luke's School (disambiguation)
- St. Luke's Church (disambiguation)
- St Luke's Hospital (disambiguation)
disambiguation page lists articles associated with the title St Luke's.
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